Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 15(3); 2008
  • Article

Review

Korean Journal of Biological Psychiatry 2008;15(3):152-74. Published online: Mar, 1, 2008

Abstract PDF Full Text

Schizophrenia and Immunological Abnormalities

  • Hee Yeon Jung, MD, PhD1.3; and Yong-Sik Kim, MD, PhD2,3;
    1;Department of Neuropsychiatry, Seoul National University, Boramae Medical Center, Seoul, 2;Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 3;Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, Korea
Abstract

There have been vast amount studies regarding immunologic dysregulation in schizophrenia. The mechanism of immune pathogenesis in schizophrenia still is unclear, even though various immune dysfunction have been reported. We endeavored to report on two major hypothesis on immunologic dysregulation in schizophrenia, the infection hypothesis and autoimmune hypothesis. We went on to focus on the autoimmune hypothesis, which has received the most attention over the years. We explored the accumulated data and the rational behind the autoimmune hypothesis and the implications of the autoimmune hypothesis for future research in the pathogenesis of schizophrenia.

Keywords Schizophrenia;Immune dysregulation;Autoimmune hypothesis.