Oct, 1, 2023

Vol.30 No.2, pp. 84-88


Review

  • Korean Journal of Biological Psychiatry
  • Volume 19(4); 2012
  • Article

Review

Korean Journal of Biological Psychiatry 2012;19(4):179-86. Published online: Apr, 1, 2012

Depression and Executive Dysfunction in Stroke

  • Kyoung-Sae Na, MD;Shin-Gyeom Kim, MD;Soyoung Irene Lee, MD; and Han-Yong Jung, MD
    Department of Psychiatry, College of Medicine, Soonchunhyang University, Bucheon Hospital, Bucheon, Korea
Abstract

Depression and executive dysfunction are common neuropsychiatric sequelae of stroke. Patients with stroke are more predisposed to depression and executive dysfunction compared to patients with similar degree of physical disability. Both depression and executive dysfunction are also associated with poor prognosis such as high mortality and delayed recovery after stroke. Complex neurobiological and anatomical mechanisms are associated with the development of depression and executive dysfunction after stroke. Activation of pro-inflammatory cytokines is thought to be associated with onset of depression, whereas injuries in frontal-subcortical circuit are thought to be a link between depression and executive dysfunction. Early detection of depressive symptoms and both pharmacological and non-pharmacological treatment would be helpful. In this review paper, the authors investigated 1) biological and neuroanatomical substrate for poststroke depression and executive dysfunction, 2) the relationship and common etiopathology for poststroke depression and executive dysfunction, and 3) pharmacological and non-pharmacological treatment for poststroke depression. The contents of the paper are as follows : the prevalence, clinical manifestation, and biological etiology for poststroke depression, neuroanatomical abnormalities as a common etiological factor for depression and executive dysfunction, pharmacotherapy and non-pharmacological approach.

Keywords Stroke;Depression;Executive dysfunction;Antidepressant.