Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 21(4); 2014
  • Article

Review

Korean Journal of Biological Psychiatry 2014;21(4):151-60. Published online: Apr, 1, 2014

Abstract PDF Full Text

The Sex-Related Differences of Relationships between 2D : 4D Ratio and Electroencephalographic Coherence in Patients with Schizophrenia Compared with Controls

  • Byungha Choi, MD1;Yu Sang Lee, MD1;Eun-Seun Han, MD1;Seongkyun Kim, MS2;Jaeseung Jeong, PhD2;Seungyeoun Lee, PhD3; and Bum joon Kim, MD4;
    1;Department of Psychiatry, Yong-In Mental Hospital, Yongin, 2;Department of Bio and Brain Engineering, KAIST, Daejeon, 3;Department of Mathematics and Statistics, Sejong University, Seoul, 4;Department of Neurology, Asan Medical Center, Seoul, Korea
Abstract

Objectives : Prenatal testosterone is known to influence both cerebral laterality and 2nd to 4th digit ratio (2D : 4D). Epigenetic changes are thought to play some role in it. We studied sex-related differences between 2D : 4D and cerebral laterality in patients with schizophrenia and controls to examine the effects of prenatal testosterone in the development of schizophrenia.

Methods : Forty one men (18 schizophrenic patients and 23 controls) and 40 women (17 schizophrenic patients and 23 controls) were recruited from one psychiatric hospital in Korea. The 2D : 4D and electroencephalographic (EEG) coherence in 19 channels (66 pairs of interhemispheric coherence and 54 pairs of intrahemispheric coherence) were measured. The sex-related statistical analyses between 2D : 4D and EEG coherence in controls and patients with schizophrenia were performed using multiple regression.

Results : In male patients, the relationship between 2D : 4D and right intrahemispheric EEG coherence showed mainly positive correlation in delta and theta frequency bands, while it showed negative correlation in male controls. In female patients, the relationship between 2D : 4D and interhemispheric EEG coherence showed stronger positive correlation in alpha and beta frequency bands, while it showed weaker positive correlation in female controls.

Conclusions : Low prenatal testosterone may play certain roles in altered correlation between 2D : 4D and cerebral laterality in schizophrenia and the development of schizophrenia by epigenetic mechanism.

Keywords 2D : 4D;EEG coherence;Sex;Cerebral laterality;Schizophrenia.