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2021 Impact Factor 1.766
5-Year Impact Factor 1.674
Korean Journal of Biological Psychiatry 2018;25(1):16-20. Published online: Jan, 1, 2018
Objectives :
Psychological resilience is the ability to cope with stress. The genetic background behind psychological resilience is not much known. The serotonin transporter and dopamine transporter are implicated in stress related psychology and emotional processing. The aim of this study is to investigate a possible genetic role of functional polymorphisms of serotonin and dopamine transporters for psychological resilience.
Methods : A total of 951 healthy adult subjects were included. Psychological resilience was measured using Connor-Davidson Resilience Scale (CD-RISC). Genotyping was performed for
serotonin transporter gene (SERT) promoter variable number tandem repeat (VNTR) and dopamine
transporter gene (DAT1) 3'-untranslated region (UTR) VNTR. Genetic association analysis was conducted between genotypes and the CD-RISC score.
Results : No genetic association was observed for SERT promoter VNTR or
DAT1 3'-UTR VNTR with CD-RISC score. No genetic interaction between SERT promoter VNTR and DAT1
3'-UTR VNTR with CD-RISC score was detected.
Conclusions : Either serotonin or dopamine transporter did not seem to play a significant role for psychological resilience in this sample.
Keywords CD-RISC;Dopamine;Gene;Psychological resilience;Serotonin.