Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 4(1); 1997
  • Article

Review

Korean Journal of Biological Psychiatry 1997;4(1):48-53. Published online: Jan, 1, 1997

Abstract PDF Full Text

Effect of Antipsychotic Drugs on Dopamine Transporter Function in CV (Bdat) Cells

  • Young-Mi Kim, PhD1;Yong-Sung Lee, MD, PhD1;Sang-Hun Lee, MD, PhD1;Dong-Yul Oh, MD, PhD2;Byung-Hwan Yang, MD, PhD3;Suck-Shin Cho, MD, PhD4; and Jung-Hyun Nam, MD, PhD3;
    1;Department of Biochemistry, 4;Nuclear Medicine, College of Medicine, Hanyang University, Seoul, 2;National Seoul Mental Hospital, 3;Department of Neuropsychiatry, College of Medicine & Mental Health Research Institute, Hanyang University, Seoul, Korea
Abstract

CV(bDAT) cell line, expressing dopamine transporter stably, has been established by transfection of CV-1 cells with bovine dopamine transporter cDNA. Using CV(bDAT) cells, the effects of various antipsychotic drugs on dopamine uptake activity were investigated. All of antipsychotic drugs tested, inhibited the ［3H］dopamine uptake into CV(bDAT) cells with IC50s in the low to mid micromolar range, implying that antipsychotic drugs may produce overflow of dopamine in the synaptic cleft of dopaminergic neuron.

Keywords Dopamine transporter;Dopamine uptake;Antipsychotic drug.