Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 4(1); 1997
  • Article

Review

Korean Journal of Biological Psychiatry 1997;4(1):54-9. Published online: Jan, 1, 1997

Abstract PDF Full Text

Effects of the Sanjoin on the Rat Brain - Focused on Serotonin, Sleeping Time, Sleep EEG and Autonomic Activity -

  • Hee-Yeon Jeong, MD1;Young-Joon Kwon, MD1;In-Joon Park, MD1;Joon-Taek Kwon, MD2Byung-Hoon Han, MD3; and Sung-Pil Lee, MD4;
    1;Department of Neuropsychiatry, Soonchunhyang Chun-an Hospital, Chun-an, 2;Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Seoul, 3;Natural Products Research Institute, Seoul National University, Seoul, 4;Department of Neuropsychiatry, St. Vincent Hospital, Catholic University Medical College, Suwon, Korea
Abstract

Objects：Sanjoin, the seeds of Zizyphus vulgaris var. spinosus has been used as the most important hypnotic agent in chinese medicine to treat insomnia. This research was performed in order to examine the effect of betulinic acid and sanjoinine-A which are components of Sanjoin.

Method：Sleeping time, sleep recordings of EEG, EMG, serum serotonin level, and locomotor activity were measured in rats which received betulinic acid and sanjoinine-A as sleep induction material extracted from Sanjoin.

Results：1) Groups received betulinic acid, sanjoinine-A, and lorazepam showed increased sleep time than control group with saline. 2) Groups with betulinic acid, sanjoinine-A, lorazepam and saline recorded β-wave in sleep recordings of EEG. In EMG, there was no significant difference among all groups. 3) No significant difference in serum serotonin level among all groups was found. 4) In autonomic activity testing, groups of betulinic acid, sanjoinine-A, and lorazepam showed significantly more decreased in activity than saline group. In comparison of groups of betulinic acid and sanjoinine-A with a group of lorazepam, there was no significant difference.

Conclusion：These results suggest that betulinic acid and sanjoinine-A have the sedative effect like lorazepam rather than sleep effect.

Keywords Sanjoin;Sanjoinine-A;Betulinic acid;Serotonin;Sedative effect.